Outsourcing a metabolic or endocrine program means matching a CRO or CDMO to the disease biology: diabetes, obesity, NASH, dyslipidemia, thyroid, and rare endocrine disorders. The work spans target validation, DIO and db/db mouse models, glucose clamps, GLP-1 and incretin pharmacology, peptide and biologic manufacturing, and clinical trials. On BioBridgeX, buyers source and compare vetted suppliers free, then contract directly with the supplier they choose.
Metabolic / Endocrinology CRO and CDMO vendors (138)
UNIQ Trials
Apeloa Pharmaceutical
TRiCBIO
VCHP Clinical Solutions
AAPharmaSyn
Famar Group
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Nipro PharmaPackaging
CDMO · Drug Product Manufacturing, Aseptic Fill-Finish, QC & Release Testing
AbbVie Contract Manufacturing
CRO & CDMO · Drug Substance: Small Molecule / API, Drug Substance: Biologics, Formulation Development
Singota Solutions
CDMO · Aseptic Fill-Finish, Drug Product Manufacturing, QC & Release Testing
Novocol Pharma
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Lifecore Biomedical
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Kindeva Drug Delivery
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Grand River Aseptic Manufacturing (GRAM)
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Curia Global
CRO & CDMO · Drug Substance: Small Molecule / API, Drug Substance: Biologics, Formulation Development
Jubilant HollisterStier
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Siegfried Holding
CRO & CDMO · Drug Substance: Small Molecule / API, Formulation Development, LNP / Delivery Formulation
Aenova Group
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Fresenius Kabi Contract Manufacturing
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Simtra BioPharma Solutions
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
Vetter Pharma
CDMO · Formulation Development, LNP / Delivery Formulation, Process Development
PCI Pharma Services
CDMO · Aseptic Fill-Finish, Drug Product Manufacturing, Formulation Development
BSP Pharmaceuticals
CDMO · ADC / Bioconjugation, Aseptic Fill-Finish, Drug Product Manufacturing
WuXi STA (STA Pharmaceutical)
CDMO · Peptide / Oligo Synthesis, Drug Substance: Small Molecule / API, ADC / Bioconjugation
CPC Scientific
CDMO · Peptide / Oligo Synthesis, Process Development, Analytical Development
Senn Chemicals (Granules India)
CDMO · Peptide / Oligo Synthesis, Process Development, Analytical Development
Recipharm
CDMO · mRNA / RNA Manufacturing, LNP / Delivery Formulation, Drug Product Manufacturing
Evonik (Health Care)
CDMO · LNP / Delivery Formulation, Formulation Development, Drug Product Manufacturing
Ajinomoto Bio-Pharma Services
CRO & CDMO · Peptide / Oligo Synthesis, ADC / Bioconjugation, Drug Substance: Small Molecule / API
CSBio
CDMO · Peptide / Oligo Synthesis, Process Development, Analytical Development
Agilent Technologies
CDMO · Peptide / Oligo Synthesis, Process Development, Analytical Development
ST Pharm
CDMO · Peptide / Oligo Synthesis, mRNA / RNA Manufacturing, Process Development
Nitto Avecia Pharma Services
CDMO · Peptide / Oligo Synthesis, Process Development, Analytical Development
WuXi TIDES (WuXi AppTec)
CRO & CDMO · Peptide / Oligo Synthesis, ADC / Bioconjugation, Medicinal & Synthetic Chemistry
Kaneka Eurogentec
CDMO · Peptide / Oligo Synthesis, Plasmid DNA Manufacturing, Drug Substance: Biologics
PolyPeptide Group
CDMO · Peptide / Oligo Synthesis, Process Development, Analytical Development
Viralgen (AskBio)
CDMO · Viral Vector Manufacturing, Process Development, Analytical Development
Catalent
CDMO · Viral Vector Manufacturing, Cell Therapy Manufacturing, Plasmid DNA Manufacturing
Wacker Biotech
CDMO · Process Development, Analytical Development, Drug Substance: Biologics
Richter BioLogics (Richter-Helm)
CDMO · Process Development, Analytical Development, Drug Substance: Biologics
BioVectra
CDMO · Process Development, Analytical Development, Drug Substance: Biologics
Boehringer Ingelheim BioXcellence
CDMO · Cell Line / Strain Development, Process Development, Analytical Development
WuXi Biologics
CDMO · Cell Line / Strain Development, Process Development, Analytical Development
Teva API (TAPI)
CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Laurus Labs (Laurus Synthesis)
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
Navin Molecular (Navin Fluorine)
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
F.I.S. (Fabbrica Italiana Sintetici)
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
PROCOS
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
Sumitomo Chemical (Pharmaceuticals/CDMO)
CDMO · Process Development, Drug Substance: Small Molecule / API, Analytical Development
Fermion (Orion Corporation)
CDMO · Process Development, Drug Substance: Small Molecule / API, Analytical Development
Minakem (Minafin Group)
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
Curia (formerly AMRI)
CRO & CDMO · Target ID & Validation, Hit-to-Lead, Lead Optimization
Bachem
CDMO · Peptide / Oligo Synthesis, Process Development, Analytical Development
Veranova
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
Pfizer CentreOne
CRO & CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Noramco
CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Thermo Fisher Scientific (Patheon)
CRO & CDMO · Process Development, Drug Substance: Small Molecule / API, Analytical Development
Divi's Laboratories
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
Dr. Reddy's Custom Pharma Services (CPS)
CRO & CDMO · Process Development, Drug Substance: Small Molecule / API, Analytical Development
Piramal Pharma Solutions
CRO & CDMO · Hit-to-Lead, Lead Optimization, Medicinal & Synthetic Chemistry
EUROAPI
CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Olon Group
CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Fareva
CRO & CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
DOTTIKON ES
CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
CordenPharma
CRO & CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
WuXi STA (WuXi AppTec)
CRO & CDMO · Medicinal & Synthetic Chemistry, Process Development, Analytical Development
Asymchem
CRO & CDMO · Medicinal & Synthetic Chemistry, Process Development, Drug Substance: Small Molecule / API
Siegfried
CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Cambrex
CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Lonza
CRO & CDMO · Drug Substance: Small Molecule / API, Process Development, Analytical Development
Eurofins (Pharma Discovery & Bioanalytical Services)
CRO & CDMO · Bioanalytical Services, Central Laboratory Services, Genetic Toxicology
QPS Holdings
CRO · Bioanalytical Services, DMPK / ADME, GLP Toxicology
Sannova Analytical
CRO · Bioanalytical Services, Immunogenicity & Immunotoxicology, Biomarker Discovery & Development
NorthEast BioLab
CRO · Bioanalytical Services, Immunogenicity & Immunotoxicology, Biomarker Discovery & Development
Simulations Plus
CRO · PK/PD & Modeling, DMPK / ADME, In Vitro / Early Toxicology
Certara
CRO · PK/PD & Modeling, Biostatistics & Statistical Programming, Medical Writing
ACM Global Laboratories
CRO · Central Laboratory Services, Biomarker Discovery & Development, Bioanalytical Services
Labcorp
CRO & CDMO · Central Laboratory Services, GLP Toxicology, Safety Pharmacology
BioModels
CRO · In Vitro Pharmacology, Biomarker Discovery & Development, PK/PD & Modeling
Pharmacology Discovery Services (PDS)
CRO · In Vitro Pharmacology, Safety Pharmacology, Assay Development & Screening
GemPharmatech
CRO · In Vitro Pharmacology, Target ID & Validation, Biomarker Discovery & Development
Biocytogen
CRO · In Vitro Pharmacology, Target ID & Validation, Biomarker Discovery & Development
Labcorp (Labcorp Drug Development)
CRO · In Vitro Pharmacology, DMPK / ADME, GLP Toxicology
WuXi AppTec (WuXi Biology)
CRO & CDMO · In Vitro Pharmacology, DMPK / ADME, Bioanalytical Services
The Jackson Laboratory (JAX)
CRO · In Vitro Pharmacology, Biomarker Discovery & Development, Target ID & Validation
Hypha Discovery
CRO · Medicinal & Synthetic Chemistry, DMPK / ADME, Bioanalytical Services
ChemDiv
CRO · Assay Development & Screening, Hit-to-Lead, Lead Optimization
BioDuro
CRO & CDMO · Target ID & Validation, Assay Development & Screening, Hit-to-Lead
Aurigene Pharmaceutical Services
CRO & CDMO · Target ID & Validation, Assay Development & Screening, Hit-to-Lead
Selvita
CRO · Target ID & Validation, Assay Development & Screening, Hit-to-Lead
Sygnature Discovery
CRO · Target ID & Validation, Assay Development & Screening, Hit-to-Lead
Syngene International
CRO & CDMO · GLP Toxicology, Safety Pharmacology, DMPK / ADME
Aragen Life Sciences
CRO & CDMO · DMPK / ADME, GLP Toxicology, Safety Pharmacology
Sai Life Sciences
CRO & CDMO · DMPK / ADME, In Vitro / Early Toxicology, GLP Toxicology
JOINN Laboratories / Biomere
CRO · GLP Toxicology, Safety Pharmacology, Toxicokinetics (TK)
KCAS Bio
CRO · Bioanalytical Services, Biomarker Discovery & Development, Immunogenicity & Immunotoxicology
IQVIA Laboratories (Q2 Solutions)
CRO · Bioanalytical Services, Biomarker Discovery & Development, DMPK / ADME
Nuvisan
CRO & CDMO · DMPK / ADME, Bioanalytical Services, In Vitro / Early Toxicology
Biotrial
CRO · Safety Pharmacology, GLP Toxicology, Toxicokinetics (TK)
BioAgilytix
CRO · Bioanalytical Services, Immunogenicity & Immunotoxicology, Biomarker Discovery & Development
Scantox
CRO · GLP Toxicology, Safety Pharmacology, Genetic Toxicology
Cyprotex (an Evotec company)
CRO · In Vitro / Early Toxicology, DMPK / ADME, Genetic Toxicology
Evotec
CRO & CDMO · In Vitro / Early Toxicology, DMPK / ADME, Safety Pharmacology
Crown Bioscience
CRO · In Vitro Pharmacology, Biomarker Discovery & Development, Assay Development & Screening
Frontage Laboratories
CRO & CDMO · GLP Toxicology, Safety Pharmacology, Toxicokinetics (TK)
Eurofins Discovery
CRO · In Vitro / Early Toxicology, Safety Pharmacology, DMPK / ADME
WuXi AppTec
CRO & CDMO · GLP Toxicology, Safety Pharmacology, Genetic Toxicology
Inotiv
CRO · GLP Toxicology, Safety Pharmacology, Genetic Toxicology
Labcorp (Labcorp Drug Development / former Covance)
CRO & CDMO · GLP Toxicology, Safety Pharmacology, Genetic Toxicology
Charles River Laboratories
CRO & CDMO · GLP Toxicology, Safety Pharmacology, Genetic Toxicology
Avance Clinical
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
Cromos Pharma
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
George Clinical (Emerald Clinical)
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Precision for Medicine
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Pharmaron
CRO & CDMO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
WuXi Clinical
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
Tigermed
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
CMIC Group
CRO & CDMO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Linical
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Altasciences
CRO & CDMO · Phase 1 / Early Clinical Unit, Clinical Operations, Bioanalytical Services
Celerion
CRO · Phase 1 / Early Clinical Unit, Clinical Operations, Bioanalytical Services
ClinChoice
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Emmes
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
ProPharma
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Novotech
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Premier Research
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Veristat
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Caidya
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Allucent
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
PSI CRO
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
Worldwide Clinical Trials
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
Syneos Health
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
Medpace
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
Fortrea
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
PPD (Thermo Fisher Scientific)
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
Parexel
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
ICON plc
CRO · Clinical Operations, Phase 1 / Early Clinical Unit, Clinical Data Management
IQVIA
CRO · Clinical Operations, Clinical Data Management, Biostatistics & Statistical Programming
What kind of CRO work does a Metabolic / Endocrinology program need?
Metabolic and endocrine programs cover a wide span of biology, and the CRO work changes a lot depending on where you sit in it. A type 2 diabetes or obesity asset, a NASH (now MASH) candidate, a dyslipidemia drug, a thyroid or adrenal program, and a rare endocrine disorder all share some plumbing but ask different questions of a supplier. What ties them together is a heavy reliance on in vivo disease models and a set of physiology readouts that a generalist lab often does not run well, so therapeutic-area depth matters more here than in some other areas.
On the discovery side the work usually starts with target validation and pharmacology in the standard metabolic model toolkit. Diet-induced obese (DIO) mice, db/db and ob/ob mice, Zucker and ZDF rats, streptozotocin-induced diabetes, and high-fat or methionine-choline-deficient diet models for steatohepatitis are the usual workhorses. The readouts are where indication expertise shows: oral and intraperitoneal glucose tolerance tests (OGTT, IPGTT), insulin tolerance tests, hyperinsulinemic-euglycemic clamps (the gold standard for insulin sensitivity and a genuinely hard procedure to run cleanly), body composition by EchoMRI or DEXA, indirect calorimetry for energy expenditure, HbA1c, lipid panels, and food-intake and body-weight tracking over weeks. For NASH you add liver histology with NAS and fibrosis staging, often read by a blinded pathologist, plus emerging non-invasive markers. A lot of the field now runs on incretin biology, so a CRO comfortable with GLP-1, GIP, glucagon, amylin, and dual or triple agonist pharmacology, including PK/PD around peptide half-life and receptor selectivity, is worth seeking out.
Many of these molecules are peptides, antibodies, or other biologics, which pulls CDMO capability into the picture early. That means peptide synthesis or recombinant expression, formulation work for stability and injectability (and increasingly oral peptide delivery), lyophilization, fill-finish, and the analytical methods to support them. On the safety and clinical side you will need IND-enabling tox, then clinical execution that understands endocrine endpoints and the regulatory expectations: cardiovascular outcome considerations for diabetes drugs, glycemic endpoints like HbA1c reduction, weight-loss percentage endpoints for obesity, and the FDA and EMA history around this class. Diabetes and obesity trials also run large and long, so patient access, endocrinology site networks, and central-lab capacity for metabolic assays become real selection criteria.
How do you choose a CRO for Metabolic / Endocrinology?
The screening question is fit to your specific indication and modality, not whether the supplier has a metabolic page on its website. A lab that runs beautiful DIO obesity studies may have never validated a clamp; a NASH histology specialist is the wrong first call for a thyroid program. Put two or three suppliers against the same written scope and work the checklist below before you weigh price.
- Therapeutic-area experience: ask for relevant programs in your exact indication (diabetes, obesity, NASH/MASH, dyslipidemia, thyroid or adrenal, rare endocrine) and for the named scientists who would run your work, not just a company track record.
- Disease models and procedures: confirm they actually run the models and readouts you need in-house (DIO, db/db, ZDF, STZ, NASH diet models, OGTT/IPGTT, clamps, indirect calorimetry, body composition) rather than subcontracting the hard parts.
- Incretin and modality fit: for the current wave of GLP-1, GIP, glucagon, and amylin assets, check real experience with peptide and biologic PK/PD, receptor selectivity, and dosing schedules; for CDMO work, confirm peptide or biologic manufacturing, formulation, and stability capability.
- Endpoint and histology quality: for NASH, ask who reads the liver histology and whether scoring is blinded and consistent; for clamps and calorimetry, ask for QC data and historical variability, since these procedures are easy to run badly.
- Regulatory track record: look for prior IND/CTA packages and clinical work in this class, plus awareness of cardiovascular safety expectations for diabetes drugs and the agency history around weight and glycemic endpoints.
- Clinical capacity and patient access: for trials, confirm endocrinology and primary-care site networks, recruitment realism for large long-running studies, and central-lab capability for HbA1c, lipids, and metabolic biomarkers.
- Data quality and capacity: documented SOPs, traceable raw data, GLP status where the study supports a filing, and an honest read on current queue and turnaround so a booked-solid lab does not quietly become your timeline risk.
Frequently asked questions
What disease models do CROs use for metabolic and diabetes studies?
Which readouts and endpoints matter most in metabolic pharmacology studies?
Do I need a CRO that specializes in GLP-1 and incretin drugs?
What should I look for in a CRO for a NASH or MASH program?
How does BioBridgeX work, and what does it cost a buyer?
Can one supplier cover both preclinical studies and manufacturing for a metabolic asset?
Source Metabolic / Endocrinology work with one contract
Compare transparent quotes from qualified Metabolic / Endocrinology CRO and CDMO vendors, then contract once. Free for buyers.
Compare quotes